Bloomsbury is an area of the London Borough of Camden, between Euston Road and Holborn. It was developed by the Russell family in the 17th and 18th centuries into a fashionable residential area. It is notable for its garden squares, literary connections, and numerous cultural, educational and health care institutions. Bloomsbury Square was laid out in 1660 by Thomas Wriothesley, 4th Earl of Southampton. Much of the district was planned and built by James Burton.